Coenzyme q0 from antrodia cinnamomea in submerged cultures induces reactive oxygen species-mediated apoptosis in a549 human lung cancer cells
Journal
Evidence-based Complementary and Alternative Medicine
Journal Volume
2014
Date Issued
2014
Author(s)
Abstract
We investigated the anticancer effects of Antrodia cinnamomea, a medicinal mushroom from Taiwan, on A549 human lung cancer cells using the ethyl acetate extract from submerged culture filtrates. Our results showed that 2,3-dimethoxy-5-methyl-1,4-benzoquinone (coenzyme Q0; CoQ0) derived from A. cinnamomea submerged culture filtrates has anticancer activity. CoQ0 treatment reduced the viability of A549, HepG2, and SW480 cancer cell lines. Furthermore, CoQ0 induced reactive oxygen species (ROS) generation and apoptosis in A549 cells, which was inhibited by the antioxidant ascorbic acid. To our knowledge, these data demonstrate for the first time that CoQ0 derived from A. cinnamomea submerged culture filtrates exerts its anticancer effect through the induction of ROS-mediated apoptosis in A549 human lung cancer cells. ? 2014 Cheng-Han Chung et al.
SDGs
Other Subjects
2,3 dimethoxy 5 methyl 1,4 benzoquinone; acetic acid ethyl ester; Antrodia cinnamomea extract; ascorbic acid; cytotoxic agent; plant extract; plant medicinal product; reactive oxygen metabolite; unclassified drug; A549 cell line; antineoplastic activity; Antrodia cinnamomea; apoptosis; Article; biomass; cell death; cell survival; cell viability; HepG2 cell line; human; human cell; nonhuman; priority journal; submerged fermentation
Type
journal article