Host susceptibility to non-tuberculous mycobacterial infections
Journal
The Lancet Infectious Diseases
Journal Volume
15
Journal Issue
8
Pages
968-980
Date Issued
2015
Author(s)
Holland S.M.
Abstract
Non-tuberculous mycobacteria cause a broad range of clinical disorders, from cutaneous infections, such as cervical or intrathoracic lymphadenitis in children, to disseminated infections at all ages. Recognition of the underlying immune defect is crucial for rational treatment, preventive care, family screening, and, in some cases, transplantation. So far, at least seven autosomal mutations (in IL12B, IL12RB1, ISG15, IFNGR1, IFNGR2, STAT1, and IRF8) and two X-linked mutations (in IKBKG and CYBB), mostly presenting in childhood, have been reported to confer susceptibility to disseminated non-tuberculous mycobacterial infection. GATA2 deficiency and anti-interferon γ autoantibodies also give rise to disseminated infection, typically in late childhood or adulthood. Furthermore, isolated pulmonary non-tuberculous mycobacterial infection has been increasing in prevalence in people without recognised immune dysfunction. In this Review, we discuss how to detect and differentiate host susceptibility factors underlying localised and systemic non-tuberculous mycobacterial infections. ? 2015 Elsevier Ltd.
SDGs
Other Subjects
interferon consensus sequence binding protein; STAT1 protein; transcription factor GATA 2; atypical mycobacteriosis; autosomal dominant inheritance; bacterial immunity; ciliary dyskinesia; cystic fibrosis; disease predisposition; family; gain of function mutation; gene mutation; genotype; granuloma; host resistance; host susceptibility; human; intracellular killing; lung disease; macrophage activation; priority journal; prognostic assessment; prophylaxis; Review; signal transduction; treatment failure; treatment outcome; treatment response; atypical mycobacteriosis; genetic predisposition; genetics; mutation; Genetic Predisposition to Disease; Humans; Mutation; Mycobacterium Infections, Nontuberculous
Publisher
Lancet Publishing Group
Type
review