Changes in magnetic resonance bone marrow angiogenesis on day 7 after induction chemotherapy can predict outcome of acute myeloid leukemia
Journal
Haematologica
Journal Volume
95
Journal Issue
8
Pages
1420-1424
Date Issued
2010
Abstract
Recently, dynamic contrast-enhanced magnetic resonance imaging has been shown to be a on-invasive technique that provides global and functional imaging of bone marrow angiogenesis in acute myeloid leukemia. To assess the clinical implication of changes in angiogenesis shortly after induction chemotherapy, dynamic contrastenhanced magnetic resonance imaging was performed prospectively before treatment (day 0) and on day 7 in 80 patients with de novo acute myeloid leukemia. We demonstrated that a post-therapeutic reduction in Peak (negative ΔPeak) compared with the day 0 value was significantly associated with a higher chance of achieving complete remission, and better overall and disease free survival (P=0.022, 0.003 and 0.007, respectively). Cox's multivariate analysis also identified negative ΔPeak value as an independent good prognostic factor for overall and disease free survival. Our findings provide evidence that the change of Peak on day 7 relative to pre-treatment levels may be a relevant biomarker for early identification of patients who may fail conventional induction chemotherapy ClinicalTrials.gov Identifier: NCT00172562).? 2010 Ferrata Storti Foundation.
SDGs
Other Subjects
anthracycline; cytarabine; gadolinium pentetate meglumine; idarubicin; acute granulocytic leukemia; adolescent; adult; aged; article; bone marrow disease; cancer chemotherapy; clinical trial; contrast enhancement; controlled clinical trial; controlled study; disease free survival; drug efficacy; drug megadose; female; high risk patient; human; image analysis; leukemia remission; major clinical study; male; nuclear magnetic resonance imaging; outcome assessment; overall survival; prognosis; treatment response; tumor vascularization; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Neovascularization, Pathologic; Predictive Value of Tests; Prognosis; Time Factors; Treatment Outcome; Young Adult
Type
journal article