Photocontrolled targeted drug delivery: Photocaged biologically active folic acid as a light-responsive tumor-targeting molecule
Journal
Angewandte Chemie - International Edition
Journal Volume
51
Journal Issue
35
Pages
8806-8810
ISSN
1521-3773
Date Issued
2012-07-25
Author(s)
Abstract
Light-controlled: Biodegradable nanoparticles encapsulating an anticancer drug (red dots in picture) have been synthesized that carry photocaged folate groups on the surface. Upon irradiation the photocaging group (green) is removed and the free folate group, a tumor-homing agent, binds to folate receptors on cell surfaces, thus leading to specific targeting and cellular uptake.
Subjects
cytotoxicity
drug delivery
nanoparticles
photocaging
prodrugs
SDGs
Publisher
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Type
journal article