Serum adiponectin levels are associated with hepatitis B viral load in overweight to obese hepatitis B virus carriers
Journal
Obesity
Journal Volume
21
Journal Issue
2
Pages
291-296
Date Issued
2013
Author(s)
Abstract
Objective: This study aimed to investigate the association between serum adiponectin and chronic hepatitis B virus (HBV) infection. Design and Methods: We conducted a campus-based cross-sectional study in Northern Taiwan, an HBV-endemic country. A total of 506 participants, including 147 chronic HBV-infected individuals and 359 healthy controls, were assessed for anthropometric indices, serum adiponectin levels, serum HBV viral load and markers, serum alanine aminotransferase levels and metabolic factors. Results: Older age, male gender, higher alanine aminotransferase, higher body mass index, greater waist circumference, lower fasting glucose, higher triglycerides, and higher adiponectin were associated with chronic HBV infection in univariate analyses. In multivariate analysis, the presence of chronic HBV infection was positively associated with serum adiponectin levels (P < 0.0001) and high adiponectin levels over the 75th percentile (odds ratio, 4.25; 95% confidence interval, 2.36-7.66; P < 0.0001) after adjusting for age, gender, body mass index, and insulin resistance index. Furthermore, serum adiponectin levels were positively associated with HBV viral load in overweight to obese HBV-infected subjects (P = 0.018). Conclusion: Although chronic HBV-infected individuals were heavier than healthy controls, they had significantly higher serum adiponectin levels than healthy counterparts. Additionally, adiponectin levels were positively associated with HBV viral load in overweight to obese HBV-infected subjects. Future research should focus on elucidating adiponectin pathways, which may contribute to the development of adjuvant treatments for chronic HBV infection.
SDGs
Other Subjects
adiponectin; alanine aminotransferase; cholesterol; glucose; triacylglycerol; adult; age; alanine aminotransferase blood level; anthropometry; article; body mass; controlled study; cross-sectional study; diet restriction; female; gender; hepatitis B; Hepatitis B virus; human; insulin resistance; major clinical study; male; nonhuman; obesity; protein blood level; risk factor; Taiwan; virus load; waist circumference; Adiponectin; Adult; Alanine Transaminase; Biological Markers; Blood Glucose; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Hepatitis B; Hepatitis B virus; Humans; Insulin; Insulin Resistance; Linear Models; Multivariate Analysis; Obesity; Odds Ratio; Overweight; Risk Factors; Taiwan; Viral Load; Young Adult; Hepatitis B virus
Type
journal article