飼糧二十二碳六烯酸對豬隻脂質代謝基因表現之影響(1/3)
Date Issued
2003
Date
2003
Author(s)
DOI
912313B002405
Abstract
Dietary fatty acid composition can change fatty acid profiles in several porcine
tissues, such as adipose tissue, muscle, and liver（Innis et al., 1996；Ding et al., 2003）.
Hsu (2002) demonstrated 2% DHA oil in the diet will significantly increased the
DHA in several porcine tissues. Such changes also inhibited the expression of
hepatic Sterol Regulatory Element-Binding Protein-1（SREBP-1） mRNA .
The purpose of current project was to test the effect of dietary high DHA, high n-6
polyunsaturated fatty acid (PUFA), and n-3 PUFA on blood composition and gene
expression in several tissues. Dietary DHA supplementation for two d decreased
plasma triacylglycerol (TG) and cholesterol concentration（P＜0.001）. Dietary
soybean oil treatment decreased plasma TG but not cholesterol concentration.
Northern analysis demonstrated that DHA treatment reduced the SREBP1 mRNA
concentration in the liver. The DHA treatment also increased the ACO mRNA
concentration. Soybean oil treatment did not have the same effect. The SREBP1
regulates the expression of several lipogenic genes. Therefore, dietary DHA
treatment may reduce lipogenic pathway due to inhibition of SREBP1 expression.
Taken together, dietary DHA treatment may improve nutrients utilization and produce
high DHA meat products.
Subjects
ADD1
DHA
SREBP1
Publisher
臺北市：國立臺灣大學動物科學技術學系暨研究所
Type
report
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