Cytotoxic and anti-inflammatory cembranoids from the Dongsha Atoll soft coral Sarcophyton crassocaule
Journal
Bioorganic and Medicinal Chemistry
Journal Volume
18
Journal Issue
5
Pages
1936-1941
Date Issued
2010
Author(s)
Abstract
Five new cembranoids, sarcocrassocolides A-E (1-5), along with three known cembranoids 6-8, have been isolated from a Formosan soft coral Sarcophyton crassocaule. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and the absolute configuration of 1 was determined by a modified Mosher's method. Compounds 1-4 exhibited significantly cytotoxic activity against a limited panel of cancer cell lines. Compounds 1-4, 6 and 8 were shown to exert significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells. Compound 6 also significantly inhibited the accumulation of pro-inflammatory COX-2 protein. ? 2010 Elsevier Ltd. All rights reserved.
Subjects
Cembranoids; Inflammatory; Sarcocrassocolides; Sarcophyton crassocaule; Soft coral
Other Subjects
cembranoid; cyclooxygenase 2 inhibitor; inducible nitric oxide synthase; sarcocrassocolide a; sarcocrassocolide b; sarcocrassocolide c; sarcocrassocolide d; sarcocrassocolide e; unclassified drug; animal cell; antiinflammatory activity; article; carbon nuclear magnetic resonance; controlled study; coral; cytotoxicity; drug activity; drug isolation; drug structure; heteronuclear multiple bond correlation; human; human cell; nonhuman; nuclear Overhauser effect; protein expression; proton nuclear magnetic resonance; rat; Sarcophyton crassocaule; spectroscopy; Animals; Anthozoa; Anti-Inflammatory Agents; Cell Line, Tumor; Cyclooxygenase 2; Diterpenes; Drug Screening Assays, Antitumor; Humans; Macrophages; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; Alcyonacea; Sarcophyton crassocaule
Type
journal article