Reduced Gastric Mucosal Nerve Density in Functional Dyspepsia: Clinical Significance and Functional Correlation.
Journal
The American journal of gastroenterology
Journal Volume
120
Journal Issue
6
Pages
1405 - 1408
ISSN
1572-0241
Date Issued
2025-01-03
Author(s)
Yang, Yao-Chun
Cheng, Ya-Yin
Wei, Jing-Jung
Lin, Cheng-Chen
Yeh, Ti-Yen
Chi-Chao Chao
Abstract
INTRODUCTION:The aim of this study was to quantitatively examine gastric mucosal nerve density (GMND) in patients with functional dyspepsia (FD) and analyzed its clinical correlation.METHODS:We prospectively enrolled 35 patients with FD and 16 age-matched and gender-matched healthy controls for comparison of GMND on endoscopic biopsy, scores of Gastroparesis Cardinal Symptom Index, and gastric emptying scintigraphy.RESULTS:Patients with FD had lower GMND than the controls in gastric antrum, body, and fundus. GMND was inversely correlated with the Gastroparesis Cardinal Symptom Index scores, but not correlated with gastric emptying scintigraphy parameters.DISCUSSION:GMND was reduced in FD and inversely correlated with the symptom severity. © 2025 by The American College of Gastroenterology.
Subjects
Gastroparesis Cardinal Symptom Index, gastric emptying scintigraphy
endoscopic biopsy
functional dyspepsia
gastric mucosal nerve density
SDGs
Type
journal article