Acute pancreatitis and amiodarone: A case report
Journal
World Journal of Gastroenterology
Journal Volume
13
Journal Issue
6
Pages
975-977
Date Issued
2007
Author(s)
Abstract
Amiodarone, a class III antiarrhythmic drug, is one of the most effective drugs used in the treatment of ventricular and paroxysmal supraventricular tachyarrhythmia. Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood. A 66-year old woman with acute pancreatitis was admitted to our hospital with the complaint of epigastralgia radiating to both flanks for two months. Her symptoms and elevation of pancreatic enzymes did not respond to conventional medical treatment of pancreatitis for 18 d. No known causal factors for pancreatitis such as biliary tract stone, hypertriglyceridemia and alcohol consumption could be identified. Under the suspicion of armodarone-induced acute pancreatitis, amiodarone was substituted by propafenone. Her symptoms soon alleviated and serum lipase level declined. Three months after hospital discharge, the abdominal pain did not recur: Amiodarone was approved to treat recurrent ventricular fibrillation or sustained ventricular tachyarrhythmia that has been resistant to other medications since 1986. Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature. We report a patient who developed acute pancreatitis during amiodarone therapy. ? 2007 The WJG Press. All rights reserved.
Subjects
Acute pancreatitis; Amiodarone; Amylase; Lipase
SDGs
Other Subjects
amiodarone; digitalis; digoxin; furosemide; pancreas enzyme; propafenone; quinidine; spironolactone; triacylglycerol lipase; warfarin; abdominal pain; acute cholecystitis; acute pancreatitis; aged; aorta valve replacement; article; artificial heart pacemaker; case report; cholecystectomy; cholelithiasis; clinical feature; computer assisted tomography; drug dose reduction; drug substitution; drug withdrawal; dyspnea; epigastric pain; female; flank pain; follow up; functional status; heart atrium fibrillation; human; hysterectomy; laboratory test; mitral valve replacement; ovary cyst; physical examination; radiofrequency ablation; rheumatic heart disease; salpingooophorectomy; sick sinus syndrome; side effect; tachycardia; triacylglycerol lipase blood level; uterus myoma
Publisher
WJG Press
Type
journal article