Reversed association between levels of prostate specific antigen and levels of blood cadmium and urinary cadmium
Journal
Chemosphere
Journal Volume
83
Journal Issue
8
Pages
1188-1191
Date Issued
2011
Author(s)
Abstract
Prostate cancer associated with cadmium exposure may indicate a link between prostate specific antigen (PSA) and levels of blood cadmium (BCd) and urinary cadmium (UCd). Thus, these associations were investigated. We recruited 295 men, 50years of age and above from a health check-up program at a health center as subjects of the study. They completed a self-reported questionnaire and provided fasting samples of blood and urine for cadmium assay. The assay was performed using atomic absorption spectrophotometry. Blood samples were also collected for the assays of total cholesterol and high-density lipoprotein measures. The means of BCd and UCd increased with age and the means of all subjects were 1.19±1.04μgL-1 and 1.37±1.76μgg-1 creatinine, respectively. The PSA levels were positively associated with the lipid levels, but reversely associated with BCd and UCd levels. The multivariate logistic regression analysis showed that men with PSA?4.0ngmL-1 had an odds ratio (OR) of 0.4 (95% CI=0.1-0.9) to have BCd>0.49μgL-1, and an OR of 0.4 (95% CI=0.2-1.0) to have UCd>0.45μgg-1 creatinine. In conclusion, the PSA levels are reversely associated with BCd and UCd levels. ? 2010 Elsevier Ltd.
Subjects
Blood cadmium; Prostate specific antigen; Taiwan; Urinary cadmium
SDGs
Other Subjects
Antigens; Binary alloys; Cadmium; Diseases; Regression analysis; Urology; Atomic absorption spectrophotometry; Blood cadmium; Cadmium exposure; High density lipoprotein; Multivariate logistic regressions; Prostate specific antigen; Taiwan; Total cholesterols; Blood; cadmium; cholesterol; creatinine; lipoprotein; prostate specific antigen; antigen; atomic absorption spectroscopy; blood; cadmium; cancer; lipid; public health; regression analysis; spectrophotometry; urine; adult; aged; article; atomic absorption spectrometry; bioassay; blood level; blood sampling; cholesterol blood level; controlled study; disease association; health center; human; major clinical study; male; multivariate logistic regression analysis; prostate cancer; questionnaire; regression analysis; risk; urine level; Taiwan
Publisher
Elsevier Ltd
Type
journal article