Studies on the chemical constituents of the root of Cimicifuga heracleifolia (L.)
Date Issued
2006
Date
2006
Author(s)
Lu, Chao-Tsen
DOI
zh-TW
Abstract
Cimicifuga heracleifolia (L.) distributes over mainland China. It has been used as anti-inflammatory, and antipyretic agents in Chinese medicine.
The methanol extract from the root of Cimicifuga heracleifolia (L.) was concentrated to give a residue which was partitioned between ethyl acetate and water. The ethyl acetate layer was separated by column chromatography on silica gel, preparative thin layer chromatography and high performance liquid chromatography (HPLC) to give 46 compounds. Among these compounds, 10 new and 4 isolated for the first time from natural sources are elucidated. The
total isolated included 21 cycloartanes, 5 coumarins, 4 chromones, 9 aromatic compounds, 2 indoles, 3 apocarotenoids, and 2 steroids.
By means of IR spectra, 1H NMR spectra, 13C NMR spectra (1D and 2D techniques) and Mass spectra, Of these compounds, the chemical structures of these compounds are determined. The known compounds were identified by
spectral analysis and compared with those reported in literatures or from
authentic samples.
Subjects
天然物分離
升麻
三萜
cimicifuga heracleifolia
cycloartane
HPLC
Type
thesis
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