Hollow-fiber liquid-phase microextraction combined with capillary electrophoresis for trace analysis of sulfonamide compounds
Journal
Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Journal Volume
942
Pages
134-140
Date Issued
2013
Author(s)
Tong, Fanghong
Zhang, Yang
Chen, Fang
Li, Ying
Ma, Guanhua
Chen, Yanping
Liu, Kun
Dong, Jiaming
Ye, Jiannong
Chu, Qingcui
Abstract
A hollow-fiber liquid-phase microextraction (HF-LPME) method has been developed for the preconcentration of trace sulfonamides in water samples. Six commonly used sulfonamides including sulfamethazine (SMZ), sulfamerazine (SMR), sulfadiazine (SDZ), sulfadimethoxine (SDM), sulfamethoxazole (SMX), and sulfathiazole (STZ) were determined by CE with electrochemical detection (CE-ED) after microextraction. Several factors that affect extraction efficiency, separation, and detection were investigated. Under the optimum conditions, above sulfonamide compounds could achieve baseline separation within 35min, exhibiting a linear calibration over three orders of magnitude (r(2)≥0.998); the obtained enrichment factors were between 121 (for SDZ) and 996 (for SDM), and the LODs were in the range of 0.033-0.44ng/mL. The proposed HF-LPME/CE-ED method has been applied for the sensitive analyses of the real-world water samples with recoveries in the range of 75.1-109%.
SDGs
Type
journal article