與肝細胞再生有關之生長因子接受體在肝細胞癌的表現
Other Title
Expression of receptors of growth
factors related to liver
regeneration in hepatocellular
carcinoma
factors related to liver
regeneration in hepatocellular
carcinoma
Date Issued
1999
Date
1999
Author(s)
李嘉哲
DOI
882314B002192
Abstract
high recurrence rate and poor long
term survival of patients with
hepatocellular carcinoma (HCC)
receiving operation remains a serious clinical problem. After partial hepatectomy, hepatocyte growth factor, interlukin-6,transforming growth
factor and epidermal growth factor
contribute to the regeneration of liver.
We examined 40 surgical resected HCC
samples to determin whether the
receptors of above growth factors were
expressed in HCC and how they
correlated with tumor recurrence.We
found that most of the HCC did express
receptors for growth factors.The
amount of receptors did not correlate
with the tumor size.The recurrence of
HCC did not correlate with the amount
of receptors in tumor tissue,age,sex,
HBsAg,Anti-HCV and presence of liver
cirrhosis.There is size difference of
interleukin 6 receptor between
nontumor and tumor tissue in 71%cases.
In conclusion,HCC expresses receptors
for growth factors related to liver
regeneration.The recurrence of HCC did
not related to expression of growth
factor receptors.The growth of HCC is
probably mainly controlled by
different mechanisms from liver regeneration.
Subjects
hepatocellular carcinoma
hepatocyte growth factor
interleukin 6
transforming growth
factor
factor
epidermal growth factor
receptor
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
882314B002192.pdf
Size
24.95 KB
Format
Adobe PDF
Checksum
(MD5):4784bb09f616fa860ee34f4346d73aa2