Helicobacter Pylori Infection is Positively Associated with Metabolic Syndrome in Taiwanese Adults: A Cross-Sectional Study
Journal
Helicobacter
Journal Volume
20
Journal Issue
3
Pages
184-191
Date Issued
2015
Author(s)
Abstract
Background: Helicobacter pylori infection and metabolic syndrome have been reported to be positively associated. However, only a few studies have focused on this issue, and H. pylori serum antigen was used to diagnose infection in most of them. We aimed to investigate the association between metabolic syndrome factors and H. pylori infection, as diagnosed via a 13C-urea breath test. Materials and Methods: This cross-sectional study consisted of 3578 subjects (18-64 years old) enrolled from one health management center between 2008 and 2013. H. pylori infection was defined as a positive urea breath test. The risk of metabolic syndrome from H. pylori infection was assessed using a multiple logistic regression model. Results: The prevalence of the H. pylori was similar in both genders (20.6% in men and 19.7% in women). H. pylori -infected participants had significantly higher body mass index, fasting glucose, low-density lipoprotein, and triglycerides, and lower high-density lipoprotein (p < 0.05), than uninfected ones (p < 0.05). The prevalence of metabolic syndrome was higher in H. pylori -infected subjects than uninfected ones (men: 12.4% vs. 7.4%, p < 0.001; women: 7.4% vs. 2.5%, p < 0.001). Furthermore, H. pylori infection prevalence increased with metabolic score (P for trend <0.001, both sexes). Moreover, the association between metabolic syndrome and UBT positivity was significant in females (OR 1.91, 95% CI:1.03-3.53), but only borderline significant in males (OR 1.38, 95% CI: 0.97-1.95). Conclusion: H. pylori infection is positively associated with metabolic syndrome, especially in females. The causal relationship between H. pylori infection and metabolic syndrome warrants further investigation. ? 2015 John Wiley & Sons Ltd.
SDGs
Other Subjects
glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; urea c 13; high density lipoprotein; low density lipoprotein; urea; adult; aged; Article; body mass; cholesterol blood level; cross-sectional study; diastolic blood pressure; disease association; endocrine function test; female; glucose blood level; Helicobacter infection; human; major clinical study; male; metabolic syndrome X; priority journal; sex difference; systolic blood pressure; triacylglycerol blood level; urea breath test; waist circumference; adolescent; Asian continental ancestry group; breath analysis; complication; Helicobacter Infections; Helicobacter pylori; isolation and purification; metabolic syndrome X; metabolism; middle aged; prevalence; statistical model; Taiwan; young adult; Helicobacter pylori; Adolescent; Adult; Asian Continental Ancestry Group; Breath Tests; Cross-Sectional Studies; Female; Helicobacter Infections; Helicobacter pylori; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Logistic Models; Male; Metabolic Syndrome X; Middle Aged; Prevalence; Taiwan; Urea; Young Adult
Publisher
Blackwell Publishing Ltd
Type
journal article