Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967
Journal
Marine Drugs
Journal Volume
18
Journal Issue
6
Date Issued
2020
Author(s)
Abstract
Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus giganteus NTU967 isolated from Ulva lactuca exhibited significant antimicrobial activity in our preliminary screening of bioactive fungal strains. Therefore, column chromatography of the active principles from liquid- and solid–state fermented products of the fungal strain was carried out, and which had led to isolation of eleven compounds. Their structures were determined by spectral analysis to be seven new highly oxygenated polyketides, namely aspergilsmins A–G (1–7), along with previously reported patulin, deoxytryptoquivaline, tryptoquivaline and quinadoline B. Among these, aspergilsmin C (3) and patulin displayed promising anticancer activities against human hepatocellular carcinoma SK-Hep-1 cells and prostate cancer PC-3 cells with IC50 values between 2.7–7.3 ?M. Furthermore, aspergilsmin C (3) and patulin exhibited significant anti-angiogenic functions by impeding cell growth and tube formation of human endothelial progenitor cells without any cytotoxicity. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Subjects
Aspergillus giganteus; Aspergilsmin; Bioactive natural products; Polyketides; Trichocomaceae
SDGs
Other Subjects
angiogenesis inhibitor; antineoplastic agent; aspergilsmin A; aspergilsmin B; aspergilsmin C; aspergilsmin D; aspergilsmin E; aspergilsmin F; aspergilsmin G; deoxytryptoquivaline; lactate dehydrogenase; paclitaxel; patulin; polyketide; quinadoline B; sorafenib; tryptoquivaline; unclassified drug; antineoplastic agent; polyketide; antiangiogenic activity; antineoplastic activity; Article; Aspergillus giganteus; carbon nuclear magnetic resonance; cell growth; controlled study; cytotoxicity; fungal strain; fungus isolation; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; human; human cell; IC50; nonhuman; proton nuclear magnetic resonance; solid state fermentation; stem cell; animal; Aspergillus; cell proliferation; chemistry; drug effect; sea; tumor cell line; Animals; Antineoplastic Agents; Aspergillus; Cell Line, Tumor; Cell Proliferation; Humans; Inhibitory Concentration 50; Oceans and Seas; PC-3 Cells; Polyketides
Type
journal article