Control of homeostasis of CD8+ memory T cells by opposing cytokines
Journal
Science
Journal Volume
288
Journal Issue
5466
Pages
675-678
Date Issued
2000
Author(s)
Abstract
Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.
Type
journal article