Computational Materials Science of Bionanomaterials: Structure, Mechanical Properties and Applications of Elastin and Collagen Proteins
Part Of
Handbook of Nanomaterials Properties
Start Page
941
End Page
962
ISBN (of the container)
9783642311079
9783642311062
ISBN
9783642311079
9783642311062
Date Issued
2014
Author(s)
Abstract
Elastin and collagen are two major protein components found in the extracellular matrix (ECM) in various tissues of the body. Collagen is the most abundant protein in the ECM, providing necessary structural support to tissues. Elastin, by contrast, provides elasticity and recoil, very important in tissues such as the lungs, blood vessels, and skin. Both proteins are essential to healthy function, and mutations and deficiencies in either one may lead to disease. In this chapter, we consider the hierarchical assembly and structure of elastin and collagen and review the mechanical properties of both proteins across different length scales. We then consider key computational studies that have provided insight into specific functions or dysfunctions of elastin and collagen. In our focus on elastin, we provide an overview of computational studies that have explored the source of elastin’s elasticity and identified its peculiar property of assuming increased structure upon heating, a property termed the inverse temperature transition, significant for potential application of elastin in novel biomaterials. In our focus on collagen, we discuss the rare genetic disorder, osteogenesis imperfecta, also known as brittle bone disease, where mechanical and structural effects have been identified through experimental and computational studies at multiple scales.
Subjects
Collagen
Elasticity
Elastin
Hierarchical structure
Inverse temperature transition
Materiomics
Osteogenesis imperfecta (OI)
Publisher
Springer Berlin Heidelberg
Type
book part