The Study of the Expression of Co-inhibitory and Co-stimulatory Molecules in Hepatic Infiltrating Lymphocytes in Chronic Viral Hepatitis
Date Issued
2007
Date
2007
Author(s)
Wan, Chuan
DOI
en-US
Abstract
Viral infection in liver is a serious problem worldwide. There are millions of people infected with viral hepatitis and many of those progress to chronic virus infection of the liver. The etiology of persistent viral infection and poor immune response to clear these viruses remains for further elucidation. Recently some studies shed light on the importance of co-inhibitory molecules in compromising the function of virus specific cytotoxic T cells. Chemokine receptors also are known to play important roles in the homing of lymphocytes into the specific organs.
First, we tried to find out whether there is any difference in the expression of co-stimulatory/co-inhibitory molecules in peripheral blood lymphocytes and hepatic infiltrating lymphocytes. We then evaluated the correlation between these molecules. A chemokine receptor CXCR6, a recruiting molecule for lymphocytes to inflamed liver, was studied for its expression in chronic viral hepatitis patients and for the relationship between its expression and co-stimulatory/co-inhibitory molecules.
In this study, we found that PD-1 molecule expression was increased and CD28 molecule expression was decreased in the liver infiltrating lymphocytes (LILs) compared to their expressions in the peripheral blood lymphocytes (PBLs). There is an increase of CXCR6 expression in LILs. In hepatic infiltrating lymphocytes, the number of PD-1+CXCR6+CD3+T cells is increased compared with the number of these cells in PBLs. There was a low expression level of CD127, the marker of exhausted lymphocytes, in the LILs compared to the PBLs. The higher expression of PD-1 and lower CD28 expression in liver infiltrating lymphocytes might be suggestive of the impairment of LIL function in chronic hepatitis. Besides, the number of PD-1+CXCR6+CD3+ T cells is increased in LILs. This finding may imply the recruited hepatic infiltrating lymphocytes have impaired function.
Subjects
周邊血細胞
肝浸潤細胞
共同抑制性分子
共同刺激性分子
PBLs
LILs
co-inhibitory molecules
co-stimulatory molecules
SDGs
Type
other
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