Association of pancreatic autoantibodies and human leukocyte antigen haplotypes with resolution of diabetes mellitus after therapy for hepatitis C virus infection in patients with HIV infection: Case report and review of literature
Journal
European Journal of Gastroenterology and Hepatology
Journal Volume
21
Journal Issue
4
Pages
388-391
Date Issued
2009
Author(s)
Abstract
Diabetes mellitus (DM) is a well known complication of interferon therapy for chronic hepatitis C virus (HCV) infection, but resolution of interferon-induced DM was rarely reported. In HIV and HCV co-infected patients, only two cases of incident DM during interferon therapy were reported and both cases required permanent insulin treatment. We report the first case of HIV/HCV co-infected patient who developed diabetic ketoacidosis during treatment for chronic HCV infection with complete resolution of DM after treatment cessation. Review of reported cases indicates that pancreatic autoantibodies and human leukocyte antigen haplotypes may predict the outcome of interferon-induced diabetes.
SDGs
Other Subjects
autoantibody; glutamate decarboxylase; leukocyte antigen; peginterferon alpha2a; ribavirin; robatrol; unclassified drug; adult; article; case report; clinical feature; diabetes mellitus; haplotype; hepatitis C; human; Human immunodeficiency virus infection; human tissue; liver biopsy; male; priority journal; Adult; Antiviral Agents; Autoantibodies; Diabetes Mellitus, Type 2; Haplotypes; Hepatitis C, Chronic; HIV Infections; HIV-1; HLA-D Antigens; Humans; Interferon Alfa-2a; Male; Pancreas; Polyethylene Glycols; Remission, Spontaneous
Type
journal article