Prenatal Multiple Exposure and the Intelligence of 7 Year-Old Children: Comparison of Statistical Analysis Methods
Date Issued
2016
Date
2016
Author(s)
Chen, Yu-Chun
Abstract
⭺88; Background: Prenatal exposure to environmental pollutant has been associated with detrimental effects to neurodevelopment. However, the effects of mixtures between intelligence in childhood have not been studied. Aims: To evaluate the associations between pre- and perinatal biomarker concentrations of environmental pollutants and child intelligence at 7 years of age. ⭺88; Methods: The mother-child pairs enrolled in a Taiwan Birth Panel Study (TBPS) at a medical center in Taipei from May 2004 to January 2005. We collected their cord blood for measuring heavy metals (Cd, As, Pb, Hg, Mn, Cu, Se, Zn), phthalates (MEP, MnBP, MBzP, MEHP, MECPP, MCMHP, MiNP), perfluroalkyl chemicals (PFOA, PFNA, PFOS, PFUA), pesticide (Flucythrinate, Cypermethrin, Chlorpyrifos), phenols (BPA, NP, OP) and Cotinine. To assess the intelligence outcome in children at 7 year-old, Comprehensive the Wechsler intelligence scale 4th edition (WISC-IV) were used, whose indicates full scale IQ (FSIQ), verbal comprehension index (VCI), perceptual reasoning index (PRI), working memory index (WMI) and processing speed index (PSI). We used a multiple imputation approach to impute the missing exposure values. We estimated the associations between environment pollutants and IQ scores in Partial Least Squares (PLS) Regression and we also compared various statistical analysis methods, included factors analysis method, stepwise selection method, and elastic net selection method. ⭺88; Results: The higher concentrations of BPA, OP, PFNA, PFUA and Cu were associated with children’s IQ. The significances were observed as BPA in Full-Scale IQ Score ( FSIQ ) (β:-1.54; 95% CI:-3.04, -0.04), Verbal Comprehension (VCI)(β:-1.91; 95 % CI:-3.43, -0.40), Perceptual Reasoning (PRI)(β:-1.94; 95% CI:-3.58, - 0.31); PFNA in Processing Speed (PSI)(β:-2.45; 95% CI:-4.03, -0.88); Cu in Working Memory (WMI)(β:-22.30; 95% CI:-43.41, -1.19)inversely associated with FSIQ; in factors analysis method factor analysis method in the exposure concentrations of phenolic third quintile (β - 7.78; 95% CI: -12.27, -3.29) was negatively correlated with FSIQ; in stepwise selection method PFOS, PFUA , BPA and OP were more impact on FSIQ; in elastic net selection method can be seen that BPA was the most impact on FSIQ . ⭺88; Conclusions: Prenatal exposure to BPA, PFNA, and Cu were adversely associated with intelligence at age of 7 years in our study population. The PLS modeling approach and elastic net may prove useful for similar environmental epidemiology analyses of multiple exposures.
Subjects
Prenatal exposure
Multiple exposure
neural development
IQ
children
statistical analysis methods
Type
thesis
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