IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ
Journal
Nature Immunology
Journal Volume
12
Journal Issue
2
Pages
144-150
Date Issued
2011
Author(s)
Hsu L.-C.
Enzler T.
Seita J.
Timmer A.M.
Lai T.-Y.
Yu G.-Y.
Temkin V.
Sinzig U.
Aung T.
Nizet V.
Weissman I.L.
Karin M.
Abstract
Transcription factor NF-κB and its activating kinase IKKβ are associated with inflammation and are believed to be critical for innate immunity. Despite the likelihood of immune suppression, pharmacological blockade of IKKβ-NF-κB has been considered as a therapeutic strategy. However, we found neutrophilia in mice with inducible deletion of IKKβ (Ikkβ(Δ) mice). These mice had hyperproliferative granulocyte-macrophage progenitors and pregranulocytes and a prolonged lifespan of mature neutrophils that correlated with the induction of genes encoding prosurvival molecules. Deletion of interleukin 1 receptor 1 (IL-1R1) in Ikkβ(Δ) mice normalized blood cellularity and prevented neutrophil-driven inflammation. However, Ikkβ(Δ)Il1r1(-/-) mice, unlike Ikkβ(Δ) mice, were highly susceptible to bacterial infection, which indicated that signaling via IKKβ-NF-κB or IL-1R1 can maintain antimicrobial defenses in each other's absence, whereas inactivation of both pathways severely compromises innate immunity.
Type
journal article