Retinal Circular RNA hsa_circ_0087207 Expression Promotes Apoptotic Cell Death in Induced Pluripotent Stem Cell-Derived Leber’s Hereditary Optic Neuropathy-like Models
Journal
Biomedicines
Journal Volume
10
Journal Issue
4
Pages
788
Date Issued
2022
Author(s)
Yang Y.-P.
Chang Y.-L.
Lai Y.-H.
Tsai P.-H.
Hsiao Y.-J.
Nguyen L.H.
Lim X.-Z.
Weng C.-C.
Ko Y.-L.
Hwang D.-K.
Chen S.-J.
Chiou S.-H.
Chiou G.-Y.
Wang A.-G.
Chien Y.
Abstract
: Our data indicated that hsa_circ_0087207 upregulation distinguishes the disease phenotype manifestations between iPSC-derived RGCs generated from the LHON patient and carrier. Targeting the hsa_circ_0087207/miR-665 axis might hold therapeutic promises for the treatment of LHON.
SDGs
Publisher
MDPI
Type
journal article