大腸標的藥物制放：酸鹼敏感性高分子薄膜應用於5-FU制放及其對Caco-2細胞的影響
Date Issued
2002-07-31
Date
2002-07-31
Author(s)
王正一
DOI
902213E002074
Abstract
Recently, malignancy is the leading
cause of mortality in Taiwan, and colon
cancer accounted approximately 3000 deaths
each year. In the recent decade, the most
useful drug for therapy of colon cancer is
5-Fluorouracil (5-FU). It has been reported
to have considerable toxicity and side effects
administered by intravenous injections or via
alimentary treat and would be metabolized
by liver that result in the half-life only
10~15 minutes in human. Thus, it would be
clinically beneficial to localize 5-FU to a
particular site within the gastrointestinal
tract, either to maximize the therapeutic
response to the colon, or to reduce the side
effects caused by drug delivered to an
inopportune region other than target site.
In this study, pH-sensitive polymers
with the capability of selectively releasing
drug in desired compartment for
colon-specific drug delivery was prepared by
PAA/EVAL blends. The swelling degree
and the 5-FU permeation of PAA/EVAL
membranes prepared at 60℃ are functioning
as protective carriers of drugs in the pH 2.0.
The 5-FU permeation at pH 2.0 was small,
which indicates that drugs are protected in
the acidic environment. But the pH-sensitive
character disappeared gradually at 45℃ and
25℃ of membrane preparation, because the
effect of pore size is more than electrical
repulsion between adjacent carboxylate ions.
This suggests the PAA/EVAL membrane
prepared at 60℃ is a potential material for
the specific delivery of drugs to the colon for
local treatment.
Subjects
Polymer membrane
colon-specific drug delivery
SDGs
Publisher
臺北市：國立臺灣大學醫學工程學研究所
Type
report
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