Independent association of uric acid levels with peripheral arterial disease in Taiwanese patients with Type 2 diabetes
Journal
Diabetic Medicine
Journal Volume
21
Journal Issue
7
Pages
724-729
Date Issued
2004
Author(s)
Abstract
Aims: Hyperuricaemia may be a risk factor for atherosclerotic disease. Its association with peripheral arterial disease (PAD) has not been studied in Taiwanese patients with Type 2 diabetes. Methods: Uric acid (UA) levels and PAD were evaluated in 508 Taiwanese outpatients with Type 2 diabetes (210 men, 298 women; mean age ± SD, 63.8 ± 10.6 years). PAD was diagnosed when the ankle-brachial index was < 0.9. Patients with an ankle-brachial index of ? 1.3 were excluded because of possible medial arterial calcification. Potential confounding variables with P < 0.10 were adjusted for in multivariate analyses. Results: In univariate analyses, UA levels were higher in patients with PAD than in those without PAD (345.0 ± 95.2 vs. 309.3 ± 89.2 μmol/l; P < 0.0005). Prevalences of PAD for quintiles of UA levels were 6.8, 8.9, 10.2, 13.1 and 16.5%, respectively (P-trend < 0.05). With UA level as a continuous variable, the multivariate-adjusted odds ratio (95% confidence interval) for PAD was 1.005 (1.001-1.008) (P < 0.01). The optimal cut-off point for UA as determined by the receiver operating characteristic curve was 264.7 μmol/l. The sensitivity and specificity at this cut-off point was 82.6 and 33.3%, respectively. The area under curve was 0.60 (95% confidence interval: 0.53-0.68). The multivariate-adjusted odds ratio for PAD for UA above this level was 2.736 (1.239-6.043) (P < 0.05). The results after excluding 56 cases using diuretics were similar. Conclusions: Elevated uric acid level is a significant and independent risk factor for PAD in Taiwanese patients with Type 2 diabetes.
SDGs
Other Subjects
diuretic agent; uric acid; adult; aged; area under the curve; artery disease; article; atherosclerosis; confidence interval; controlled study; female; human; hyperuricemia; major clinical study; male; medical assessment; multivariate analysis; non insulin dependent diabetes mellitus; outpatient; risk factor; uric acid blood level; Aged; Arterial Occlusive Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Hyperuricemia; Male; Middle Aged; Peripheral Vascular Diseases; Risk Factors; Taiwan; Uric Acid
Type
journal article