Diabetes and risk of bladder cancer: A study using the National Health Insurance database in Taiwan
Journal
Diabetologia
Journal Volume
54
Journal Issue
8
Pages
2009-2015
Date Issued
2011
Author(s)
Abstract
Aims/hypothesis: Studies on the link between diabetes and bladder cancer in Asians are rare. We investigated the association between diabetes and incidence of bladder cancer by using a large national insurance database. Methods: A random sample of 1,000,000 individuals covered by the National Health Insurance was recruited. A total of 495,199 men and 503,748 women for all ages and 187,609 men and 189,762 women ?40 years old and without bladder cancer at recruitment were followed from 2003 to 2005. Cox regression evaluated the adjusted relative risk for all ages and for age ?40 years old. Results: The results were similar for all ages and for age ?40 years. In Cox models, patients with diabetes consistently showed a significantly higher relative risk ranging from 1.36 to 1.51 after adjustment for age, sex and other potential confounders. Age, male sex, nephropathy, urinary tract diseases (infection and stone) and statin use were associated with bladder cancer, but occupation, hypertension, stroke, ischaemic heart disease, peripheral arterial disease, eye disease, dyslipidaemia and medications (oral glucose-lowering agents including sulfonylurea, metformin, acarbose and thiazolidinediones, insulin, fibrates, ACE inhibitors/angiotensin receptor blockers and calcium channel blockers) were not. Chronic obstructive pulmonary disease and living in regions other than Metropolitan Taipei were associated with lower risk. Conclusions: Patients with diabetes have a higher risk of bladder cancer. The association with urinary tract diseases suggests a complex scenario in the link between bladder cancer and diabetes at different disease stages. ? 2011 Springer-Verlag.
SDGs
Other Subjects
acarbose; angiotensin receptor antagonist; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; fibric acid derivative; glitazone derivative; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin; metformin; oral antidiabetic agent; sulfonylurea; adult; age distribution; article; bladder cancer; cancer incidence; chronic obstructive lung disease; comorbidity; controlled study; diabetes mellitus; disease duration; dyslipidemia; eye disease; female; human; hypertension; ischemic heart disease; kidney disease; major clinical study; male; national health insurance; peripheral occlusive artery disease; priority journal; risk factor; sex difference; stroke; Taiwan; urinary tract disease; urinary tract infection; urolithiasis; Adult; Diabetes Mellitus; Female; Humans; Male; Risk Factors; Sex Factors; Taiwan; Urinary Bladder Neoplasms
Type
journal article