Antiviral and anti-inflammatory diterpenoids from the soft coral Sinularia gyrosa
Journal
Journal of Natural Products
Journal Volume
73
Journal Issue
6
Pages
1184-1187
Date Issued
2010
Author(s)
Abstract
Chemical investigation of the soft coral Sinularia gyrosa led to the purification of three new diterpenoids, designated as gyrosanols A-C (1-3). The structures of 1-3 were elucidated through extensive spectroscopic analyses. Compounds 1 and 2 exhibited antiviral activity against HCMV with IC 50's of 2.6 and 3.7 μM, respectively. In addition, compounds 1 and 2 showed significant anti-inflammatory activity by reducing the levels of the COX-2 protein (19.6 ± 3.9% and 29.1 ± 9.6%, respectively) in RAW 264.7 macrophages. © 2010 The American Chemical Society and American Society of Pharmacognosy.
SDGs
Type
journal article