Ambient ozone modifies the effect of tumor necrosis factor G-308A on bronchitic symptoms among children with asthma
Journal
Allergy: European Journal of Allergy and Clinical Immunology
Journal Volume
64
Journal Issue
9
Pages
1342-1348
Date Issued
2009
Author(s)
Abstract
Background: Tumor necrosis factor (TNF)-α has a recognized role in respiratory pathophysiology. One genetic variant (G-308A) in the promoter region affecting the expression of this cytokine may contribute to airway inflammatory diseases, but the studies on bronchitic symptoms were still inconclusive. Because ozone produces oxidative stress, increased airway TNF, and inflammation, the associations of the TNF-308 polymorphism with bronchitic symptoms may vary by ambient ozone exposure. Methods: We studied associations of TNF-308 genotype with bronchitic symptoms among asthmatic children in Children's Health Study. The association of TNF G-308A polymorphism with bronchitic symptoms was investigated and we also determined whether the associations vary with ambient ozone exposure. Results: Asthmatic children with TNF-308 GG genotype had a significantly reduced risk of bronchitic symptoms with low-ozone exposure (adjusted OR: 0.53; 95% CI: 0.31-0.91). The risk was not reduced in children living in high-ozone communities (adjusted OR: 1.42; 95% CI: 0.75-2.70). This difference in genotypic effects between low- and high-ozone environments was statistically significant among asthmatics (P for interaction = 0.01), but insignificant among nonasthmatic children. Conclusion: Our findings suggest a role of gene-environmental interactions on the occurrence of bronchitic symptoms among children with asthma. ? 2009 John Wiley & Sons A/S.
Subjects
Bronchitic symptoms; Children; Gene-environmental interaction; Tumor necrosis factor
SDGs
Other Subjects
tumor necrosis factor; article; asthma; bronchitis; child; controlled study; DNA polymorphism; environmental exposure; female; gene frequency; genetic variability; human; major clinical study; male; priority journal; risk factor; school child; Adolescent; Asthma; Bronchial Hyperreactivity; Child; Environmental Exposure; Female; Genotype; Humans; Male; Ozone; Polymorphism, Genetic; Promoter Regions, Genetic; Questionnaires; Tumor Necrosis Factor-alpha
Type
journal article