Monodentate and Tridentate N-heterocyclic Carbene Complexes of Silver
Date Issued
2012
Date
2012
Author(s)
Lin, Hong-Ru
Abstract
Due to their profound catalytic activity, N-heterocyclic carbene (NHC) metal complexes have been the focal point of intense research studies in recent years. Many metal NHCs have been identified as low-toxicity chemicals in humans, and their medical effects have been examined as well. Several carbene-metal complexes are found to be effective for biomedical applications. For example, NHC complexes of gold, ruthenium, and silver are active chemical components that can be discovered in commercial antitumor drugs or antimicrobial agents. In this work, several silver-NHC complexes possessing extended pi-systems have been prepared. We also demonstrated a versatile synthesis strategy for the annulation of aromatic moieties to 5,6-diamino-N-alkyl-benzimidazoles, precursors to NHCs, via condensation with designated diketo derivatives. By choosing the proper diketo species, we synthesized not only monomeric Ag NHCs, but also poly-NHC ligands that serve as potential candidates for the polymeric silver networks. These polymeric silver-carbene networks are envisioned to possess dual biomedical functions, namely, drug delivery carrier as porous host materials and active antibacterial agent after polymer degradation.
Subjects
N-heterocyclic carbenes
NHC silver complexes
biomedical application
drug
antimicrobial
Type
thesis
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