Core-shell structure of gold nanoparticles with inositol hexaphosphate nanohybrids for label-free and rapid detection by SERS nanotechnology
Journal
Journal of Nanomaterials
Journal Volume
2015
Pages
1-9
Date Issued
2015
Author(s)
Mevold, A.H.H.
Liu, J.-Y.
Huang, L.-Y.
Liao, H.-L.
Yang, M.-C.
Chan, T.-Y.
Wang, K.-S.
Wang, Y.-L.
Liu, T.-Y.
Abstract
Gold nanoparticles bound with inositol hexaphosphate (IP 6 ) (AuNPs/IP 6 ) were prepared by in situ reduction of various concentrations of IP 6 (0~320 µ M) through modified Frens method for surface‐enhanced Raman scattering (SERS) detection. The resultant AuNPs/IP 6 were subject to characterization including UV/Vis spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, and X‐ray photoelectron spectroscopy (XPS). The results showed that AuNPs with 65 µ M of IP 6 would result in a core AuNPs‐shell (IP 6 layer) structure, which exhibited the strongest SERS signal, due to the “hot spot effect” generated from the 1‐2 nm interparticle gaps of AuNPs/IP 6 nanohybrids (ionic interaction of IP 6 and Au + ). Furthermore, the reaction kinetics of Au and IP 6 were also investigated in this work. Higher concentration of IP 6 (190 and 260 µ M) will make AuNPs become irregularly shaped, because IP 6 is a basic salt and served as a pH mediator. The morphology and distribution of AuNPs were greatly improved by addition of 65 µ M of IP 6 . This novel AuNPs/IP 6 nanohybrid showed great stability and Raman enhancement. It is promising in the application of rapid and label‐free biological detection of bacteria or tumor cells.
Publisher
Hindawi Publishing Corporation
Type
journal article