Usefulness of 201Tl spect/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma
Journal
Head and Neck
Journal Volume
31
Journal Issue
6
Pages
717-724
Date Issued
2009
Author(s)
Abstract
Background. This study was designed to compare 201Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose (18F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC). Methods. Twenty-seven patients were recruited. Both 201Tl SPECT/CT and 18F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy. Results. The sensitivity and specificity for 201Tl SPECT/CT were 66.7% and 100%, and those for 18F-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios. Conclusion. 201Tl SPECT/CT is as effective as 18F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, 201Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than 18F-FDG PET. ? 2009 Wiley Periodicals, Inc.
SDGs
Other Subjects
cisplatin; epirubicin; fluorodeoxyglucose f 18; fluorouracil; folinic acid; mitomycin; thallium chloride tl 201; diagnostic agent; fluorodeoxyglucose f 18; radiopharmaceutical agent; adult; aged; article; cancer recurrence; clinical article; clinical effectiveness; controlled study; diagnostic accuracy; drug uptake; female; follow up; human; intermethod comparison; male; nasopharynx carcinoma; positron emission tomography; priority journal; recurrent cancer; sensitivity and specificity; single photon emission computer tomography; skull base; cohort analysis; comparative study; computer assisted diagnosis; methodology; middle aged; nasopharynx tumor; pathology; prediction and forecasting; probability; prospective study; roc curve; scintiscanning; skull base; statistical model; tumor recurrence; Adult; Aged; Cohort Studies; Female; Fluorodeoxyglucose F18; Humans; Image Interpretation, Computer-Assisted; Logistic Models; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Positron-Emission Tomography; Predictive Value of Tests; Probability; Prospective Studies; Radiopharmaceuticals; ROC Curve; Sensitivity and Specificity; Skull Base; Tomography, Emission-Computed, Single-Photon
Type
journal article