A review on the relationship between SGLT2 inhibitors and cancer
Journal
International Journal of Endocrinology
Journal Volume
2014
Pages
719578
Date Issued
2014
Author(s)
Lin H.-W.
Abstract
Risk of increasing breast and bladder cancer remains a safety issue of SGLT2 (sodium glucose cotransporter type 2) inhibitors, a novel class of antidiabetic agent. We reviewed related papers published before January 29, 2014, through Pubmed search. Dapagliflozin and canagliflozin are the first two approved SGLT2 inhibitors for diabetes therapy. Although preclinical animal toxicology did not suggest a cancer risk of dapagliflozin and overall tumor did not increase, excess numbers of female breast cancer and male bladder cancer were noted in preclinical trials (without statistical significance). This concern of cancer risk hindered its approval by the US FDA in January, 2012. New clinical data suggested that the imbalance of bladder and breast cancer might be due to early diagnosis rather than a real increase of cancer incidence. No increased risk of overall bladder or breast cancer was noted for canagliflozin. Therefore, the imbalance observed with dapagliflozin treatment should not be considered as a class effect of SGLT2 inhibitors and the relationship with cancer for each specific SGLT2 inhibitor should be examined individually. Relationship between SGLT2 inhibition and cancer formation is still inconclusive and studies with larger sample size, longer exposure duration, and different ethnicities are warranted. ? 2014 Hao-Wen Lin and Chin-Hsiao Tseng.
SDGs
Other Subjects
canagliflozin; dapagliflozin; placebo; sodium glucose cotransporter 2; bladder cancer; breast cancer; cancer grading; cancer risk; clinical effectiveness; diabetes mellitus; drug approval; drug effect; drug efficacy; drug safety; drug tolerability; ethnicity; food and drug administration; human; malignant neoplastic disease; nonhuman; outcome assessment; phase 2 clinical trial (topic); phase 3 clinical trial (topic); priority journal; Review; testis cancer; treatment duration
Publisher
Hindawi Limited
Type
review