Carbazole alkaloids from Clausena excavata and their biological activity
Journal
Phytochemistry
Journal Volume
43
Journal Issue
1
Pages
133-140
Date Issued
1996
Author(s)
CHE-MING TENG
Abstract
Five new carbazole alkaloids, clausines B, E, H, I and K, as well as 22 known compounds, were isolated from the stem bark of Clausena excavata. The structures were established from spectral data and chemical transformation. These compounds showed significant inhibition of rabbit platelet aggregation and caused vasocontraction. The crude methanol extract, partitioned layers and chromatographic fractions revealed the presence of promotive and inhibitive constituents, simultaneously. These results might explain the philosophy of use in Chinese medicine, in that the dose and content variation in a prescription produced different, promotive or inhibitive, effects on therapy.
Type
journal article