Progress in the development of piezoelectric biomaterials for tissue remodeling
Journal
Biomaterials
Journal Volume
307
Date Issued
2024-06-01
Author(s)
Nain, Amit
Chakraborty, Srishti
Barman, Snigdha Roy
Gavit, Pratik
Indrakumar, Sushma
Agrawal, Akhilesh
Chatterjee, Kaushik
Abstract
Piezoelectric biomaterials have demonstrated significant potential in the past few decades to heal damaged tissue and restore cellular functionalities. Herein, we discuss the role of bioelectricity in tissue remodeling and explore ways to mimic such tissue-like properties in synthetic biomaterials. In the past decade, biomedical engineers have adopted emerging functional biomaterials-based tissue engineering approaches using innovative bioelectronic stimulation protocols based on dynamic stimuli to direct cellular activation, proliferation, and differentiation on engineered biomaterial constructs. The primary focus of this review is to discuss the concepts of piezoelectric energy harvesting, piezoelectric materials, and their application in soft (skin and neural) and hard (dental and bone) tissue regeneration. While discussing the prospective applications as an engineered tissue, an important distinction has been made between piezoceramics, piezopolymers, and their composites. The superiority of piezopolymers over piezoceramics to circumvent issues such as stiffness mismatch, biocompatibility, and biodegradability are highlighted. We aim to provide a comprehensive review of the field and identify opportunities for the future to develop clinically relevant and state-of-the-art biomaterials for personalized and remote health care.
Subjects
Biomaterials | Ceramics | Composites | Piezoelectrics | Polymers | Tissue remodeling
Type
other