Role of microRNAs in hepatitis B virus replication and pathogenesis
Journal
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Journal Volume
1809
Journal Issue
11-12
Pages
678-685
Date Issued
2011
Author(s)
Abstract
The hepatitis B virus (HBV) is a widespread human pathogen and chronic HBV infection is a major risk factor for hepatocellular carcinoma (HCC). The role of microRNA (miRNA) in the replication and pathogenesis was reviewed. So far none of HBV-encoded miRNA has been identified. Cellular miRNAs have shown able to regulate HBV at the transcription level either by targeting to cellular transcriptions factors required for HBV gene expression, or by a directly binding to HBV transcripts. We also summarized the changed patterns of cellular miRNAs from hepatitis B progressing to cirrhosis and then liver cancer. The changing of a few of miRNAs, such as miR-122 or miR-21, were reproduced and worthy of further research by a deep sequencing and functional validation. These HBV-specific miRNAs should potentially become biomarkers for HBV infection and HBV-positive HCC diagnosis. The understanding of miRNA biology paved the way for applying miRNAs-based RNAi against HBV replication with minimal toxicities. This article is part of a Special Issue entitled: MicroRNAs in viral gene regulation. ? 2011 Elsevier B.V.
Subjects
Hepatitis B virus; Hepatocellular carcinoma; MicroRNA; Pathogenesis; Replication; Transcription
SDGs
Other Subjects
biological marker; cell protein; microRNA; microRNA 122; microRNA 21; unclassified drug; diagnostic test; gene expression profiling; gene expression regulation; gene function; gene therapy; hepatitis B; Hepatitis B virus; human; liver cell carcinoma; liver cirrhosis; molecular interaction; nonhuman; priority journal; review; RNA interference; sequence analysis; signal transduction; transcription regulation; virus pathogenesis; virus replication; Hepatitis B virus
Publisher
Elsevier
Type
review