個體特性對攝食含有機砷海產食物後尿中砷物種分佈之影響
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
DOI
922320B002169
Abstract
The aims of the present study were to
explore the effects of inter-individual
variability on the distribution of urinary
organic arsenic metabolites, and to what
extent the interference resulting from the
intake of seafood organic arsenic on the
urinary inorganic arsenic metabolites. Totally
38 healthy volunteers without arsenic
exposure were recruited in this
seven-and-half-day diet control study, and
were served 49.9 ±7.4 g oyster at the fourth
day’s dinner as organic arsenic exposure
source. First morning urine void were
collected during the whole study period while
after-shift urine void were collected around
dusk of the last 4 days. Finally, 21
participants with complete urine samples
were included for further urinary arsenic
determination and data analysis. Both oyster
and urine samples were analyzed with
inductive coupled plasma – mass
spectrometry for total arsenic level, and for
As III , As V , MMA, DMA, arsenobetaine
(AsBe), arsenocholine (AsCho),
trimethylarsine oxide (TMAO),
tetramethylarsonium ion (TetMA) by linked
with high performance liquid
chromatography. Results showed that, after
ingesting organic arsenic in oyster, urinary arsenic species were dominated by DMA and
AsBe, while less amounts were found for
As III , MMA, TMAO, TetMA, and an
unknown arsenic species. As V and AsCho
were seldom detected compared to others.
After controlling the oyster intake per unit
body weight, gender was shown associated
with the urinary total arsenic and AsBe
content in urine. Meanwhile, individual
variability was demonstrated among the
study participants for the DMA and AsBe
metabolism. Mixed effect model analysis
illustrated that various urinary arsenic
metabolites determined in the present study
were elevated significantly after oyster
ingestion. Besides, using the derived mixed
effect model, it is possible to predict the
urinary DMA, AsBe and total arsenic levels
of a subject ingesting a certain amount of
oyster, and the extent it may interfere with
the urinary inorganic arsenic metabolites
assessment.
Subjects
Organic Arsenic
Inorganic
Arsenic
Arsenic
Oyster
HPLC-ICP-MS
Arsenic Metabolites
Publisher
臺北市：國立臺灣大學公共衛生學院職業醫學與工業衛生研究所
Type
report
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