Secreted Phosphoprotein-1 (SPP1) Polymorphisms Are Associated with a Decreased Risk of Low Bone Mineral Density in Taiwanese Women
Date Issued
2011
Date
2011
Author(s)
Mao, Chine-Lin
Abstract
Background. Secreted phosphoprotein-1 (SPP1) is involved in the anchoring of osteoclasts to the mineral of bone matrix by binding with vitronectin receptor. A recent meta-analysis found SPP1 genetic polymorphisms were associated with bone mineral density (BMD) and fracture risk.
Methods. This is a cross-sectional study. A total of 1,319 healthy Taiwanese women aged 40 to 55 years old were recruited from MJ health screening center from October 2009 to August 2010. High versus low bone mineral density (BMD) was defined as the 1st tertile versus 2nd plus 3rd tertiles of BMD. Three common (allele frequency>5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) were selected to examine the association between sequence variants of SPP1 and BMD.
Results. Women carrying two copies of variant rs4754 had a significantly decreased risk of low BMD [adjusted OR (AOR) = 0.54, 95% CI = 0.36 - 0.81] as compared with non-carriers. Women carrying two copies of minor haplotype TGC had a decreased risk of low BMD among those with high alkaline phosphatase [AOR = 0.30, 95% CI = 0.15 - 0.64] or with low uric acid [AOR = 0.33, 95% CI = 0.16 - 0.68]. These associations remained significantly associated with low BMD after controlling for FDR. Menopausal status did not significant modify the association between SPP1 polymorphisms and low BMD.
Conclusion . Genetic polymorphisms of SPP1 were significantly associated with decreased risk of low BMD in middle-aged Asian women.
Subjects
SPP1
osteopontin
osteoporosis
bone mineral density
single nucleotide polymorphism
haplotypes
Type
thesis
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