Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
Journal
Human Genetics
Journal Volume
131
Journal Issue
7
Pages
1197-1203
Date Issued
2012
Author(s)
Hosgood III H.D.
Wang W.-C.
Hong Y.-C.
Wang J.-C.
Chen K.
Chang I.-S.
Chen C.-J.
Lu D.
Yin Z.
Wu C.
Zheng W.
Qian B.
Park J.Y.
Kim Y.H.
Chatterjee N.
Chen Y.
Chang G.-C.
Hsiao C.-F.
Yeager M.
Tsai Y.-H.
Wei H.
Kim Y.T.
Wu W.
Zhao Z.
Chow W.-H.
Zhu X.
Lo Y.-L.
Sung S.W.
Yuenger J.
Kim J.H.
Huang L.
Chen Y.-H.
Gao Y.-T.
Kim J.H.
Huang M.-S.
Jung T.H.
Caporaso N.
Zhao X.
Huan Z.
Yu D.
Kim C.H.
Su W.-C.
Shu X.-O.
Kim I.-S.
Bassig B.
Chen Y.-M.
Cha S.I.
Tan W.
Chen H.
Yang T.-Y.
Sung J.S.
Wang C.-L.
Li X.
Park K.H.
Ryu J.-S.
Xiang Y.
Hutchinson A.
Kim J.S.
Cai Q.
Landi M.T.
Lee K.-M.
Hung J.-Y.
Park J.-Y.
Tucker M.
Lin C.-C.
Ren Y.
Perng R.-P.
Chen C.-Y.
Jin L.
Chen K.-C.
Li Y.-J.
Chiu Y.-F.
Tsai F.-Y.
Fraumeni Jr. J.F.
Seow A.
Lin D.
Zhou B.
Chanock S.
Hsiung C.A.
Rothman N.
Lan Q.
Abstract
A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10 -12); however, this association did not achieve genome-wide significance (p ?? 10 -7) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10 -8; allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking. ? 2012 Springer-Verlag (outside the USA).
SDGs
Other Subjects
adult; aged; article; cancer risk; China; chromosome 3q; chromosome 3q28; controlled study; female; gene frequency; genetic association; genetic variability; genotype; human; lung adenocarcinoma; lung squamous cell carcinoma; major clinical study; priority journal; Singapore; single nucleotide polymorphism; smoking; South Korea; Taiwan; Adenocarcinoma; Asia; Carcinoma, Squamous Cell; Case-Control Studies; Female; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Lung Neoplasms; Polymorphism, Single Nucleotide; Risk; Smoking; Transcription Factors; Tumor Suppressor Proteins; Nicotiana tabacum
Type
journal article