Cytotoxic apigenin derivatives from Chrysopogon aciculatis
Journal
Journal of Natural Products
Journal Volume
75
Journal Issue
2
Pages
198-201
Date Issued
2012
Author(s)
CHE-MING TENG
Abstract
Four new apigenin derivatives, 7-de-O-methylaciculatin (1), 8-C-β-d-boivinopyranosylapigenin (2), aciculatinone (3), and 4′-O-glucosylaciculatin (4), along with eight known compounds, apigenin-8-carbaldehyde (5), kaempferol, tricin, taxifolin, 6,7,4′- trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM. ? 2012 The American Chemical Society and American Society of Pharmacognosy.
SDGs
Other Subjects
4' o glucosylaciculatin; 6,7,4' trihydroxyflavone; 7 de o methylaciculatin; 8 c beta dextro boivinopyranosylapigenin; aciculatin; aciculatinone; antineoplastic agent; apigenin 8 carbaldehyde; apigenin derivative; Chrysopogon aciculatis extract; kaempferol; luteolin 7 sulfate; plant extract; taxifolin; trans oxyresveratrol; tricin; unclassified drug; antineoplastic activity; article; chemical structure; Chrysopogon aciculatis; controlled study; cytotoxicity; drug isolation; human; human cell; medicinal plant; spectroscopy; Antineoplastic Agents, Phytogenic; Apigenin; Drug Screening Assays, Antitumor; Female; Flavonoids; HT29 Cells; Humans; Kaempferols; Molecular Structure; Poaceae; Taiwan; Chrysopogon
Type
journal article