Clinical features and factors of unfavorable outcomes for non-polio enterovirus infection of the central nervous system in northern Taiwan, 1994-2003
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
38
Journal Issue
6
Pages
417-424
Date Issued
2005
Author(s)
Yang T.-T.
Chen C.-M.
Huang F.-Y.
Abstract
This study investigated the clinical manifestations and outcomes of central nervous system (CNS) infection by enteroviruses. Cases with CNS involvement among all enterovirus-culture-positive cases from January 1995 to June 2003 were retrospectively reviewed. Among 1028 enterovirus-culture-positive cases, there were 333 cases involving the CNS. Of these, the ratio of male to female subjects was 1.78, and the mean (± standard deviation) age was 6.83 ± 5.9 years; 21 were premature neonates, and 10 failed to thrive. Disease entities included 282 cases of aseptic meningitis (84.7%), 44 cases of encephalitis (13.2%), and 7 cases of encephalomyelitis/polio-like syndrome (2.1%). Of these cases, 97.9% (326/333) had fever with peak body temperature at 38.9°C, 85% had headache and vomiting, 70% had meningeal signs, 64% had neck stiffness, 16.6% (55/333) had change of consciousness, 5.4% (18/333) had seizures and 5.2% (17/333) had myoclonic jerks. Mannitol was administered in 77.2% of patients (257/333), along with intravenous immunoglobulin in 6.6% (22/333). Twelve cases received ventilator support. One patient died of hand-foot-and-mouth disease, encephalitis plus cardiopulmonary failure, and 2 premature neonates died of hepatic failure, disseminated intravascular coagulation, sepsis-like syndrome and myocarditis. Eighteen had neurologic sequelae, including 7 with limb weakness, 5 with epilepsy, 2 with sixth cranial nerve palsy, 3 with cerebral palsy, 4 with psychomotor retardation, 2 with spasticity, and 1 with hearing loss. Factors associated with unfavorable outcomes (death or sequelae) included younger age (p=0.0003), higher peak white blood cell count (WBC) [p=0.0009] and skin rash (p=0.005). Younger age and higher peak WBC were poor prognostic factors of severe enterovirus CNS infection. Death was related to neonatal enterovirus infection and enterovirus 71 infection in young children.
SDGs
Other Subjects
antibiotic agent; immunoglobulin; mannitol; adolescent; adult; article; aseptic meningitis; assisted ventilation; blood cell count; body temperature; central nervous system; central nervous system infection; child; clinical feature; controlled study; demography; disease severity; encephalitis; encephalomyelitis; Enterovirus infection; female; human; human cell; infant; laboratory test; major clinical study; male; neurologic disease; newborn; Poliomyelitis virus; prognosis; rash; Taiwan; Adolescent; Adult; Age Factors; Central Nervous System Viral Diseases; Child; Child, Preschool; Enterovirus Infections; Female; Humans; Infant; Infant, Newborn; Male; Prognosis; Retrospective Studies; Taiwan
Type
journal article