Metabolic profiles in patients with chronic hepatitis C: A case-control study
Journal
Hepatology International
Journal Volume
2
Journal Issue
2
Pages
250-257
Date Issued
2008
Author(s)
Hsu C.-S.
Lai M.-Y.
Abstract
Background: The clinical implications of metabolic profiles in patients with chronic hepatitis C remain controversial. To study the association of metabolic abnormalities with chronic hepatitis C, we conducted a case-control study with special emphasis on serum lipid pattern, fasting blood glucose, and adiponectin. Methods: We enrolled 500 patients with chronic hepatitis C and 536 sex and age-matched controls. Unadjusted and adjusted associations of demographic and metabolic variables were estimated. Results: Chronic hepatitis C patients had higher alanine aminotransferase (ALT) and high-density lipoprotein-cholesterol levels, but lower total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol levels than controls. Stratifying ALT level according to its upper limit of normal, HCV infection was associated with younger age, female gender, and higher TC levels in chronic hepatitis C patients with normal ALT levels, but with lower TC and lower TG levels in those with abnormal ALT levels. By using multiple linear regression analyses for subjects with available adiponectin data, presence of HCV infection was independently associated with higher serum adiponectin levels. Conclusions: Metabolic profiles of chronic hepatitis C patients are affected by age, gender, serum adiponectin, and ALT levels. Further longitudinal studies are needed to clarify the complex interplay between HCV infection and metabolic profiles. ? Asian Pacific Association for the Study of the Liver 2008.
SDGs
Other Subjects
adiponectin; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; abnormal laboratory result; adenopectin blood level; adolescent; adult; age; alanine aminotransferase blood level; article; body mass; cholesterol blood level; controlled study; diet restriction; fasting blood glucose; female; glucose blood level; hepatitis C; human; major clinical study; male; metabolic parameters; priority journal; protein blood level; sex difference; triacylglycerol blood level
Publisher
Springer New York
Type
journal article