Integrated reference system for high-throughput sequence analytic and functional annotation on cross-species and multiple-tissue
Date Issued
2008
Date
2008
Author(s)
Huang, Bo-Jun
Abstract
The biologists expect to use model animal to predict non-model animal when they want to deal with sequence alignment. However, the integrated platform on cross-species and multiple-tissue for gene-protein-function inference is critical according to literature surveys on related service. Without integrated platform, researches have to download files, link the relationships between databases, and develop programs to deal with dataset manually. With the consideration of different species and multiple tissues, the complexity of platform is incredible to deal with multiple data sources for biologists. In addition, function inference for gene sequences could be done by GO (Gene Ontology) term. In this paper, we propose a framework of integrated platform with cross-species and multiple-tissue data reference, and it provides high-throughput sequence analytic tool for homology mapping. In addition, we also develop a web service to integrate different data sources and functional annotation information of GO. Computer science technology is also applied such as XML (Extensible Markup Language) for information exchange to simplify flow combination and dynamic web design and web 2.0 technology for friendly interactive interface to provide enriched information.
Subjects
DNA
cross-species
multiple-tissue
BLAST
model animal
Type
thesis
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