Effect of Zinc Content on Material Properties, Biocompatibility and Bioactivity of Partial-stabilized Cements
Date Issued
2014
Date
2014
Author(s)
Yang, Wei-Sheng
Abstract
To keep the tooth health, the technology of dental treatment is continuously processing improved. Among the sticky problems, including apical surgery and retrograde filling, root canal perforation repair, and vital pulp therapy, we are difficult to handle.
Fortunately, we could solve this problem by applying the biomaterial improvement. MTA which based on calcium silicate bioceramics is one of the alternatives that be widely applied. As the MTA serves several advantages such as good biocompatibility, bioactive and good sealing ability, it’s most widely applied at the current stage. However, MTA is not an ideal material, for example, it takes long setting time, poor handling property and toxic ions contained, it turns to be critical in clinical application. According to many studies of MTA, many advantages of MTA are based on its main component: calcium silicate, however, our previous study showed that calcium silicate bioceramics had slow hydration rate and long setting time.
Our group discovered such transitional elements that added to the calcium silicate cement, it would improve its material properties and we called this new material as Partial-Stabilized Cement (PSC). Zn is an essential trace element, that plays an important role in the body growth and development. Nevertheless, Zn also plays an important role in bone regulation, bone mineralization, stimulation of bone, inhibition of bone resorption, cell replication and differentiation of osteoblast cell. Furthermore, zinc plays an important role in medical material, because it would inhibit microbial growth.
The aim of this study is to evaluate the effect of zinc content on material properties, biocompatibility and bioactivity of PSC.
About the result, we could discover that the zinc doped to the PSC would reduce the setting time. The compressive strength and microhardness were lower than MTA, but it serves no significant differences. In the pH value, the pH value of PSC+Zn groups were closed to original value, it means this environment was much suitable for cell survival. The conclusion was confirmed form the data that the cell mortal rates of PSC+Zn groups were lower than MTA and Ca(OH)2 group. In the antibacterial test, the all experiment groups were better than control groups during 6 hours, but there were no significant different between all groups after 12 hours. This may be because of some alkalo-tolerant characteristics enabling the reduced susceptibility of E. faecalis. In addition, the zinc ion releasing concentration was lower than the minimum inhibitory concentration. In the bioactivity test, the all PSC+Zn groups were as well as MTA groups. Based upon such test, we could conclude that PSC+Zn groups were stimulate cell differentiation and mineralization.
Finally, we can make some conclusions from this study. Firstly, the zinc added to the PSC would improve its material properties. Secondly, The PSC+Zn groups were good at biocompability and bioactivity.
Subjects
介穩水泥
生醫陶瓷
含鋅鈣陶瓷
抗菌
生物活性
生物相容性
Type
thesis
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