Primary effusion lymphoma involving both pleural and abdominal cavities in a patient with hepatitis B virus-related liver cirrhosis
Journal
Journal of the Formosan Medical Association
Journal Volume
106
Journal Issue
6
Pages
504-508
Date Issued
2007
Author(s)
Abstract
Primary effusion lymphoma (PEL) is an unusual form of non-Hodgkin's lymphoma, which is characterized by lymphomatous effusion in body cavities, but no associated mass lesions. It is usually associated with an immunodeficient state most often with the human immunodeficiency virus (HIV). We describe a 54-year-old man with HIV-negative PEL, with a history of hepatitis B virus-related liver cirrhosis. Both abdominal and pleural cavities were involved; no solid tumor masses were found and bone marrow investigations were normal. The ascites and pleural effusion contained numerous pleomorphic lymphoid cells. Immunophenotyping was positive for CD138. Chromosome study showed complex cytogenetics. The genomic human herpesvirus-8 was detected in the lymphoma cells. It is postulated that the immunosuppressed state in this patient may have been caused by cirrhosis. The patient received four cycles of chemotherapy of CHOP and Picibanil (OK-432) intraperitoneal administration. However, no durable remission was achieved. Adefovir failed to halt the progressive liver failure after the development of YMDD mutant related to lamivudine. He died of sepsis and hepatic failure. ? 2007 Elsevier & Formosan Medical Association.
SDGs
Other Subjects
adefovir; alanine aminotransferase; antibiotic agent; bilirubin; creatinine; cyclophosphamide; doxorubicin; granulocyte colony stimulating factor; hepatitis B antigen; hepatitis C antigen; lactate dehydrogenase; lamivudine; picibanil; prednisolone; vincristine; abdominal distension; adult; alanine aminotransferase blood level; article; ascites; bacterial peritonitis; bilirubin blood level; biochemistry; case report; clinical assessment; clinical feature; computer assisted tomography; creatinine blood level; cytogenetics; cytology; drug withdrawal; echography; febrile neutropenia; follow up; hepatic encephalopathy; hepatitis B; Hepatitis B virus; hepatorenal syndrome; human; human cell; human tissue; hypoalbuminemia; immunohistochemistry; immunophenotyping; kidney disease; lactate dehydrogenase blood level; liver cirrhosis; liver failure; liver function; male; mortality; normochromic normocytic anemia; nuclear magnetic resonance imaging; peritoneal cavity; pleura cavity; polymerase chain reaction; primary effusion lymphoma; prothrombin time; sepsis; splenomegaly; treatment outcome
Publisher
Scientific Communications International Ltd
Type
journal article