低劑量輻射效應及流行病學研究─低劑量輻射與甲狀腺疾病之關係
Other Title
Low Dose Radiation Effect and Epidemiological Study – The Relationship
Between Low Dose Radiation and Thyr oid Diseases
Between Low Dose Radiation and Thyr oid Diseases
Date Issued
1999
Date
1999
Author(s)
張天鈞
DOI
883011B002002NU
Abstract
Background
Many people in Taiwan have
been living in buildings constructed with
60 Co-contaminated reinforcing steel bars. The
aim of the present study was to elucidate the
effect of chronic low-dose, low-dose-rate g-radiation
on the thyroid gland of residents
living in such buildings.
Methods Physical examination of the
thyroid, determination of thyroid function
and anti-thyroid microsomal antibody, and
thyroid ultrasonography were performed in
1349 residents living in the irradiated
buildings. Ultrasound-guided aspiration
cytology was done if a thyroid nodule was
found. Then the persons were stratified by
age into two groups (equal or < 15 years and
>15 years). Each group was further stratified
by radiation-exposed dose into five groups
Then odds ratio (ORs) and 95% confidence
intervals (CIs) were calculated by
unconditional logistic regression to examine
the association between the radiation-exposed
dose and the prevalence of thyroid
diseases.Findings
The prevalence of simple goiter
(euthyroid, diffuse hyperplasia of the thyroid,
and without thyroid antibody in the serum)
was related to the radiation-exposed dose.
The prevalence of autoimmune thyroiditis
without goiter was related to the radiation-exposed
dose only in the group of age more
than 15 years. The prevalence of abnormal
thyroid function was related to the radiation-exposed
dose only in the group of age less
than 15 years. There was no relationship
between the prevalence of nodular goiter,
thyroid cyst, thyroid cancer, Hashimoto's thyroiditis, presence of anti-thyroid
microsomal antibody and the radiation-exposed
dose.
Interpretation These findings suggest that
chronic low-dose and low-dose-rate g-radiation
have effect on the thyroid gland of
human beings. Diffuse hyperplasia is the
major change.
Subjects
Radiation
Thyroid
Diffuse Thyroid Hyperplasia
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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