Cyclic mechanical stretch regulates the AMPK/Egr1 pathway in tenocytes via Ca2+-mediated mechanosensing
Journal
Connective tissue research
Date Issued
2022-03-01
Author(s)
Huang, Yu-Ting
Wu, Yu-Fu
Chiu, Yi-Heng
Sun, Jui-Sheng
Abstract
Mechanical stimuli are essential for the maintenance of tendon tissue homeostasis. The study aims to elucidate the mechanobiological mechanisms underlying the maintenance of tenocyte homeostasis by cyclic mechanical stretch under high-glucose (HG) condition.
Subjects
AMPK; Egr1; Tendon; diabetic tendinopathy; intracellular calcium; mechanotransduction
SDGs
Publisher
TAYLOR & FRANCIS INC
Type
journal article