細菌脂多醣對腸胃活動之中樞調節效應
Date Issued
2000
Date
2000
Author(s)
陳啟祥
DOI
882314B002326
Abstract
System invasion of lipopolysaccharide (LPS), a bacterial endotoxin, produced severe pathological responses in host through the humoral actions of the immune factors. However, little is known about whether LPS could also implement its insult on
the internal organs through a neural mechanism. Recently, expression of the mRNA ofCDl4 (LPS-binding site) in the rat¡¦s brainstem, including the area postrema and the DVC regions, was shown autoradiographically. These medullary brainstem regions are responsible for vago-vagal reflex control of gastric function. Given the information above, it was then hypothesized that the endotoxin in the brainstem should affect the neuronal function of the DVC as well as the visceral organs that innervated. Vehicle or different doses of LPS (70, 56, 42, 28ng in PBS) was delivered directly into the DVC of adult male Wistar rat. During the experiment, the gastric acid output was monitored continuously before and after the brainstem injection. The results showed that, contrast to the control group, high dose of LPS inhibited TRH-induced acid secretion rapidly (within 10 mm) and significantly); the inhibitory effect appeared to be dose-dependent. Unilateral cervical vagotomy on the injection side of the brainstem effectively annihilated the inhibitory effect of LPS. The present results suggest that the LPS very likely has a direct action on the brainstem nuclei, which in turn, modify the visceral activity during a septic shock.
(TRH is a natural central stimulant of the gastric acid production.)
Subjects
Lipopolysaccharide
Gastric acid
Dorsal vagal motor neurons
Publisher
臺北市：國立臺灣大學醫學院口腔生物科學研究所
Type
journal article
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