Food bioactives, apoptosis, and cancer
Journal
Molecular Nutrition and Food Research
Journal Volume
52
Journal Issue
1
Pages
43-52
Date Issued
2008
Author(s)
Abstract
Apoptosis interchangeably referred to as programed cell death is a key pathway for regulating homeostasis and morphogenesis of mammalian cells and is connected with several diseases, in particular, cancer. It is widely believed that misregulation of this pathway leads to the development of cancer. Reflecting this knowledge, the mechanism of action for many currently used anticancer agents were specifically targeted to regulate the apoptotic pathway further stressing the role of programed cell death in maintaining normal homeostasis. Another widely accepted concept is the consumption of a variety of colorful foods with strong antioxidant properties. These dietary components also referred to as bioactives would help maintain a healthy body. Although for many of these bioactives exact nutritional benefits are not yet well defined, there is demonstrated scientific evidence suggesting a role for them in cancer prevention. This review summarizes the current knowledge of food bioactives that act through the signaling pathway inducing programed cell death, thus providing the evidence for these substances in cancer prevention. ? 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subjects
Apoptosis; Cancer; Death receptor; Food bioactives; Mitochondrial
SDGs
Other Subjects
antioxidant; death receptor; animal; apoptosis; cereal; chemistry; diet; food; fruit; human; neoplasm; review; signal transduction; vegetable; Animals; Antioxidants; Apoptosis; Cereals; Diet; Food; Fruit; Humans; Neoplasms; Receptors, Death Domain; Signal Transduction; Vegetables; Mammalia
Type
journal article