Depression-free after Interferon-α exposure indicates less incidence of depressive disorder: A longitudinal study in Taiwan
Journal
Brain, behavior, and immunity
Journal Volume
88
Date Issued
2020
Author(s)
SUH-FANG JENG
Chang H.-C.
Guu T.-W.
Shityakov S.
Miller A.H.
Felger J.C.
Chang J.P.-C.
Su K.-P.
Abstract
IFN-α-induced depression in patients undergoing hepatitis C virus (HCV) treatment provides powerful support for the inflammation hypothesis of depression. Most studies have focused on the occurrence of depressive symptoms, but there has been no study yet in depression-free HCV patients receiving IFN-α. We hypothesized that HCV patients who did not develop depression after IFN-α exposure might have a lower incidence of depressive disorders after the IFN-α treatment.
Subjects
Depression-free; HCV; IFN-α-induced depression; Population-based retrospective cohort study in Taiwan; Prophylactic effect
Other Subjects
alpha interferon; alpha interferon; antivirus agent; adult; Article; chronic hepatitis C; cohort analysis; comorbidity; controlled study; depression; disease association; disease duration; drug exposure; female; human; longitudinal study; major clinical study; male; medical record; middle aged; morbidity; population research; priority journal; retrospective study; risk assessment; risk factor; social status; Taiwan; urbanization; depression; incidence; Antiviral Agents; Cohort Studies; Depressive Disorder; Humans; Incidence; Interferon-alpha; Longitudinal Studies; Taiwan
Type
journal article