Stimulation and recording of cardiac contractions by using a cardiac-and-piezoelectric hybrid system
Journal
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Journal Volume
2
Pages
808-810
Date Issued
2018
Author(s)
Abstract
In this paper, we report a cardiac-and-piezoelectric hybrid system that uses a flexible piezoelectric sensor to measure the contraction profile of cardiac tissue cultured on its surface. This system is based on a cardiac-and-piezoelectric hybrid platform that we developed and reported previously. In this study, we integrate an electrical stimulating system to facilitate the maturation of cultured cardiomyocyte. Furthermore, a faraday cage was designed to minimize the electromagnetic interference for enhancing signal output. Finally, we verify the performance of this system by using a commercial drug: Isoproterenol, and the screening result showed similar range of EC50 value. Copyright ? (2018) by Chemical and Biological Microsystems Society. All rights reserved.
Subjects
Electromagnetic pulse; Hybrid systems; Piezoelectricity; Tissue culture; Cardiac contraction; Cardiac tissues; Cardiomyocytes; Electrical stimulations; Hybrid platform; Isoproterenol; Piezoelectric; Piezoelectric sensors; Heart
Type
conference paper