以非侵襲性方法研究氣喘病人呼吸道之發炎程度及對腺核甘單磷酸之反應性
Other Title
Noninvasive Assessment of the Relation Between Airway Inflammation and
Hyperresponsiveness to Adenosine Monophosphate in Asthmatic Patients
Hyperresponsiveness to Adenosine Monophosphate in Asthmatic Patients
Date Issued
2000
Date
2000
Author(s)
郭炳宏
DOI
892314B002063
Abstract
Recently, airway hyperresponsiveness
(AHR) to adenosine monophosphate
(AMP) may be a better marker of airway
inflammation than methacholine or
histamine. This study was undertaken to
assess the usefulness of noninvasive
measurements of AHR to AMP in the
assessment of airway inflammation in
asthmatics. First, we compared AHR to
AMP in 25 typical asthmatics (Group A)
and in 12 patients with cough-variant
asthma (Group B). Bronchoprovocation
was monitored by impulse oscillometry
(IOS) until respiratory resistance at 5 Hz (R5) increased for > 50% (PC50R5).
Exhaled nitric oxide (NO) was
determined using a real-time
chemiluminence analyzer. Hydrogen
peroxides (H2 O2 ) in the breath
condensate was measured by a
determined before and after AMP
inhalation challenge. The PC50R5 values
were higher in Group B (150.2 ± 70.2
mg/ml) than those in Group A (86.3 ±
60.7 mg/ml) (P < 0.001). In Group A,
there was a significant correlation (R =
0.48, p < 0.05) between AHR to AMP
and exhaled H2 O2 concentrations but not
to the levels of expired NO. After 1
month of asthma therapy, 16 patients in
Group A and 8 patients in Group B
underwent AMP bronchoprovocation
again and the PC50R5 increased to 291.3
± 95.2 and 313.6 ± 118.2 mg/ml,
respectively) (P=NS). The levels of
expired H2 O2 also decreased after steroid
therapy in both groups but we could not
find a significant difference in the levels
of expired NO. These data indicate that
AHR to AMP and expired H2 O2 , but not
expired NO, may provide noninvasive
markers that may be helpful in the
monitoring of disease activity in
asthmatics.
Subjects
Asthma
Airway inflammation
Adenosine
monophosphate airway hyperresponsiveness
monophosphate airway hyperresponsiveness
nitric oxide
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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